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Crit Rev Clin Lab Sci May-Jun; 48 3 Guder WG. Haemolysis as an influence and interference factor in clinical chemistry. J Clin Chem Clin Biochem Feb; 24 2 Paroxysmal nocturnal hemoglobinuria: insights from recent advances in molecular biology. Transfus Med Rev Oct; 15 4 Clinical features and outcomes of autoimmune hemolytic anemia: a retrospective analysis of 32 cases.
Korean J Hematol Jun; 46 2 Methemoglobinemia in an elderly patient with glucosephosphate dehydrogenase deficiency: a case report.
Oman Med J Mar; 29 2 Hemolyzed specimens: a reason for rejection or a clinical challenge? Feb; 46 2 The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease. JAMA Apr; 13 A comprehensive scheme for the systematic investigation of hemolytic anemia. Ann Clin Lab Sci Sep-Oct; 24 5 Neonatal intensive care unit quality initiative: identifying preanalytical variables contributing to specimen hemolysis and measuring the impact of evidence-based practice interventions.
Jul; 1 Bush V, Mangan L. The hemolyzed specimen: causes, effects, and reduction. Determination of hemolysis thresholds by the use of data loggers in pneumatic tube systems. Oct; 57 10 Hemolysis detection and management of hemolyzed specimens. Biochem Med Zagreb ; 20 2 Studies on in vitro hemolysis and utility of corrective formulas for reporting results on hemolyzed specimens. Biochem Med Zagreb ; 21 3 The influence of bilirubin, haemolysis and turbidity on 20 analytical tests performed on automatic analysers.
Results of an interlaboratory study. Jan; 33 1 Jay DW, Provasek D. Characterization and mathematical correction of hemolysis interference in selected Hitachi assays.
Sep; 39 9 Sonntag O. Haemolysis as an interference factor in clinical chemistry. Effects of hemolysis interferences on routine biochemistry parameters. Biochem Med Zagreb ; 21 1 In vitro and in vivo haemolysis and potassium measurement. BMJ Apr; Mather A, Mackie NR. Effects of hemolysis on serum electrolyte values. Jun; 6 3 Spurious electrolyte disorders: a diagnostic challenge for clinicians. Am J Nephrol ; 38 1 Interference of hemolysis in the estimation of plasma aspartate aminotransferase, potassium and phosphate.
Journal of Investigational Biochemistry. Hemoglobin interference from in vivo hemolysis. Sep; 31 9 Hemolysis associated with pneumatic tube system transport for blood samples. We evaluated the causes of hemolysis in samples received by our STAT section in the Department of Laboratory Medicine of the University Hospital of Padova, which performs all clinical chemistry tests on specimens collected using lithium heparin as anticoagulant Becton Dickinson.
Over a day observation period, we evaluated 27 blood specimens from 15 sample requests for clinical chemistry, coagulation, and toxicological tests. According to the study protocol, each time hemolysis was visually identified, even if it was only slight, the laboratory contacted the phlebotomists to find out the procedure utilized for vascular access, the technique used for drawing blood, and to obtain information on the transportation, preservation, and storage of the specimens.
If no errors in these procedures were identified and in vivo hemolysis was not suspected clinically, serum haptoglobin was measured immediately and at 24 h with a view to confirming the presence of any acute hemolysis, which was clinically evaluated and then confirmed in a further phase.
We identified hemolyzed specimens 3. The concentration of hemoglobin in plasma was measured by a colorimetric assay Plasma hemoglobin; Sigma-Aldrich. The percentages of hemolyzed specimens were similar in the internal medicine and surgery departments 3. In most cases it was possible to relate the presence of hemolysis to a specific cause because of the cooperation of phlebotomists and nurses, and only 26 5.
Importantly, hemolysis from excessive aspiration force was relatively frequent, mainly in the case of small or superficial veins. Another frequent cause was the presence of a partial obstruction of an arterial catheter, leading to an increase in the aspiration force when a syringe was used to collect the sample.
Yet another cause was hemolysis caused by forcing blood from a syringe into a tube, which was confirmed by observing a difference in the degree of hemolysis in the different tubes filled with blood from the same syringe.
Collection of samples by syringe was associated with a higher rate of hemolysis as In vivo hemolysis accounted for 16 of cases 3. Importantly, in 5 of the 16 cases, the presence of hemolysis was not suspected by clinicians, and the laboratory finding was essential in identifying the presence of a critical situation, thus potentially improving the medical outcome.
We conclude that: a Hemolyzed specimens are a critical preanalytical problem calling for well-designed and implemented laboratory guidelines and recommendations. The laboratory guidelines for in vivo hemolysis should include the measurement and immediate transmission of results of some laboratory tests, at least potassium in emergencies, which can provide the clinician with essential information, thus allowing identification of clinical situations requiring immediate intervention.
Plebani M, Carraro P. This review looks into current evidence concerning the causes and consequences of in vitro hemolysis, and aims to explain how to deal with it. Keywords: Affected laboratory parameters; Causes of hemolysis; Management of hemolysis; Preanalytical hemolysis.
Published by Elsevier Inc. All rights reserved. Abstract Preanalytical hemolysis of blood samples is a common problem in medical practice, especially in emergency departments. Hemolysis of blood samples. Red blood cells without left and middle and with right hemolysis.
If as little as 0.
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