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Liver damage caused by acetaminophen is a particularly serious problem. That may seem odd since Tylenol and other over-the-counter medications containing acetaminophen are so accessible, but that's part of the problem.

People often will unknowingly take more than one medication containing acetaminophen at a time. Research has found that exceeding 4, milligrams mg a day can lead to potentially irreversible and even fatal liver damage.

Accidental overdoses and even deaths may occur in this scenario. For that reason, any medication that combines acetaminophen with another ingredient can have only mg of acetaminophen. Norco, for example, comes in several strengths of hydrocodone, ranging from 2. Of the medications that can cause problems when taken while Norco is in your system, the ones that are most dangerous are those that can interact with hydrocodone, particularly benzodiazepines. These are prescription depressant drugs used most often to treat anxiety, muscle spasms, and seizures.

The best way to protect yourself from harm while taking Norco is to make sure your doctor knows about all drugs and supplements you are taking before you begin treatment. Like other opioids, the hydrocodone content of Norco can lead to tolerance and physical dependence, even if you take them exactly as prescribed. Tolerance means that people require larger doses of the drug to feel the same pain-relieving effects. If this happens, you should talk to your doctor.

Never take a larger dose than what you have been prescribed. Your doctor may adjust your dose or switch you to another type of medication. When a person develops a dependence on a drug, they need to continue taking it in order to avoid experiencing symptoms of withdrawal. When you decide to stop taking Norco or another type of opioid medication, your doctor may gradually lower your dose in a process called tapering in order to avoid withdrawal effects.

If you suspect that you might be dependent or addicted to Norco or another hydrocodone-containing medication, help is available. Start by talking to your doctor, who can help you taper off the drug and find another medication that will alleviate your pain.

Your doctor may also recommend inpatient or outpatient residential treatment or refer you to a mental health professional who specializes in addiction treatment and recovery. For more mental health resources, see our National Helpline Database.

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Excretion profile of hydrocodone, hydromorphone and norhydrocodone in urine following single dose administration of hydrocodone to healthy volunteers. J Anal Toxicol. National Institutes on Alcohol Abuse and Alcoholism. Harmful interactions. Updated Acetaminophen: Avoiding liver injury. Updated June 24, National Library of Medicine. Hydrocodone and acetaminophen overdose. Updated January Acetaminophen-induced hepatotoxicity: A comprehensive update.

J Clin Transl Hepatol. Updated October FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines; requires its strongest warning. American Addiction Centers.

Hydrocodone withdrawal: Timeline, detox and treatment. Your Privacy Rights. To change or withdraw your consent choices for VerywellMind. At any time, you can update your settings through the "EU Privacy" link at the bottom of any page. These choices will be signaled globally to our partners and will not affect browsing data. We and our partners process data to: Actively scan device characteristics for identification.

I Accept Show Purposes. Table of Contents View All. Table of Contents. How Long Does Norco Last? Factors That Affect Detection Time. Symptoms of Overdose. Getting Help. Understanding Opioid Overdoses. Alcohol Risks With Norco Alcohol and hydrocodone can cause drowsiness, dizziness, an increased risk of overdose, breathing problems, impaired motor control, unusual behavior, and memory problems.

Do not use in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. An overdose can damage your liver or cause death.

Tell your doctor if you feel an increased urge to use more of this medicine. Never share this medicine with another person, especially someone with a history of drug abuse or addiction.

Keep the medicine in a place where others cannot get to it. Selling or giving away this medicine is against the law. Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device not a kitchen spoon. If you need surgery or medical tests, tell the doctor ahead of time that you are using this medicine. You should not stop using this medicine suddenly.

Follow your doctor's instructions about tapering your dose. Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet. Since this medicine is used for pain, you are not likely to miss a dose.

Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time. Your doctor may recommend you get naloxone a medicine to reverse an opioid overdose and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up.

Your caregiver must still get emergency medical help and may need to perform CPR cardiopulmonary resuscitation on you while waiting for help to arrive. Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it. Health Topics. Health Tools. Norco Acetaminophen And Hydrocodone. Generic Name: Acetaminophen and hydrocodone. Reviewed: June 23, You should not use this medicine if you are allergic to acetaminophen or hydrocodone, or if you have: severe asthma or breathing problems; or a blockage in your stomach or intestines.